Tuesday, April 30, 2013

Analysis: U.S. emergency care cost estimates are too low

Apr. 29, 2013 ? U.S. emergency care costs may be more than twice previously published estimates, according to a new analysis that critiques those estimates, argues for improved accounting, and suggests considering the value of emergency care as well as total spending.

Alternately praised in the aftermath of horrible tragedies as a heroic service and lamented in policy debates as an expensive safety net for people without primary care, emergency medicine is often a hot topic. Despite that importance, an analysis published online April 26 in the Annals of Emergency Medicine finds that national expenditures on emergency care are likely significantly higher than previously thought.

"The ER has become increasingly important as a place where people go for acute unscheduled care, however there has been little rigorous analysis of its cost structure," said paper lead author Dr. Michael Lee, assistant professor of emergency medicine in the Warren Alpert Medical School of Brown University and a physician at Rhode Island Hospital and The Miriam Hospital.

Lee, who had a prior career in economics and finance before training in emergency medicine, co-wrote the analysis with Dr. Brian Zink, professor and chair of the Department of Emergency Medicine at the Alpert Medical School, and Dr. Jeremiah Schuur, assistant professor at Harvard Medical School and director of quality and patient safety for the Department of Emergency Medicine at the Brigham and Women's Hospital.

The challenge of properly accounting for the costs of emergency care, Lee said, becomes crucial as health care financing moves from a fee-for-service model to bundled payments for patient populations or episodes of care.

Clarifying costs

The analysis first examines current estimates of aggregate spending on emergency department (ED) care. The Agency for Healthcare Research and Quality's Medical Expenditure Panel Survey (MEPS) estimates $48.3 billion of spending on emergency care in 2010, or 1.9 percent of the nation's total health care expenditures of $2.6 trillion. With the message that "The total cost is small relative to the entire health care system," the American College of Emergency Physicians has embraced the AHRQ figure in its "Just 2 percent" public relations campaign.

How big a part of the whole bill?

A new cost analysis suggests that emergency care accounts for far more than the commonly accepted 1.9 percent of the nation's $2.6-trillion annual health care bill. It's more likely between 4.9 and 5.8 percent -- possibly as high as 6.2 to 10 percent.But Lee and his co-authors point out, based on data from other studies, that MEPS undercounts the number of ED visits and the number of ED patients who are admitted to hospitals. Adjusting for those discrepancies using data from a variety of other published sources, the authors estimate that ED costs are between 4.9 percent to 5.8 percent of total health care spending.

The authors went beyond national data sets, including the National Emergency Department Sample, to review ED spending data from a different source: a major national private insurer. The data included charges from doctors and hospitals for imaging, testing, and other procedures. But again there were accounting differences between admitted and discharged patients and a need to account fully for spending from Medicare and Medicaid. The authors' estimate based on this data is ED spending that is 6.2 to 10 percent of total health care spending.

Much of the debate in the academic literature around the expense of ED care has to do with whether the bulk of costs are fixed (e.g., expensive equipment and continuous staffing) or marginal (e.g., flexible staff time, expendable supplies). According to Lee, the cost structure of the ED remains poorly understood and is significantly more complex than what is modeled in existing studies.

As with assessments of total costs, the authors report, the studies vary widely even after adjusting for inflation. Across four major studies over the last three decades, the average cost per patient of an ED visit in 2010 dollars ranged from only $134 to more than $1,000, Lee and colleagues found. Meanwhile, the marginal cost of an ED visit (factoring out the fixed costs), ranged from $150 to $638.

Alternative accounting

The authors instead argue for an accounting based approach to ED costs using a methodology known as "Time-Driven Activity Based Costing (ABC)," which has been applied to health care by Robert Kaplan and Michael Porter, professors at the Harvard Business School.

The method maps all clinical, administrative, and diagnostic steps in a patient encounter and assigns costs to each activity, explicitly accounting for the time spent on each task.

ABC accounting might provide a more realistic and transparent measure of ED costs, Lee said, because the emphasis on time is particularly relevant for emergency medicine.

"The real cost of providing emergency care has to do with accurately measuring the resources that are used, and time is an important variable to take into account," he said.

The authors envision using the methodology to measure the cost of common ED processes or chief complaints, and to compare this to alternative sites such as primary care offices or clinics, he said. They also point out that ABC accounting gives "gives ED managers specific data they can use to improve the value of care by identifying high-cost steps in the process."

Emphasize value, not just cost

The authors acknowledge that an outcome of their analysis reporting higher overall costs for emergency care, may invite further criticism that the expense of emergency care represents unnecessary, inefficient care.

"However, we offer a more sanguine interpretation -- the high share of spending affirms the importance of emergency medicine within the health care system," they wrote. "With 130 million visits, 28 percent of all acute care visits, and accounting for nearly half of all admissions, emergency medicine should be expected to represent a large share of health care spending."

And Lee cautions, based on other studies, that efforts by private and government payers to divert ER care may not lead to large aggregate savings.

"Diverting nonemergency care may simply shift costs onto primary care offices and clinics which may not have the infrastructure to accommodate a large volume of unscheduled care," Lee said.

Instead there may be more potential for cost savings by focusing on reducing unnecessary diagnostic testing in the ED or unnecessary admissions that originate from the ED.

Lee and his co-authors call for the debate to include value, not just cost.

"More attention should be devoted to quantifying the value of specific aspects of emergency care," they wrote. "Rather than minimize the issue of cost, we should recognize the economic and strategic importance of the ED within the healthcare system and demonstrate that costs are commensurate with value.

Lee acknowledges that this remains a challenge for the field of emergency medicine. "The core of our business is ruling out critical diagnoses. Many of the things we look for are low probability but highly dangerous conditions. The big question is how do you quantify value when your work is often focused on trying to demonstrate the absence of something?"

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Story Source:

The above story is reprinted from materials provided by Brown University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Michael H. Lee, Jeremiah D. Schuur, Brian J. Zink. Owning the Cost of Emergency Medicine: Beyond 2%. Annals of Emergency Medicine, 2013; DOI: 10.1016/j.annemergmed.2013.03.029

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/-2Lv_P_FvXM/130429130514.htm

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Monday, April 29, 2013

Eyes-on: MIT Media Lab's Smarter Objects can map a user interface onto... anything (video)

Eyeson MIT Media Lab's Smarter Objects can map a user interface onto anything video

While patrolling the halls of the CHI 2013 Human Factors in Computing conference in Paris, we spied a research project from MIT's Media Lab called "Smarter Objects" that turns Minority Report tech on its head. The researchers figured out a way to map software functionality onto tangible objects like a radio, light switch or door lock through an iPad interface and a simple processor / WiFi transceiver in the object. Researcher Valentin Huen explains that "graphical user interfaces are perfect for modifying systems," but operating them on a day-to-day basis is much easier using tangible objects.

To that end, the team developed an iPad app that uses motion tracking technology to "map" a user interface onto different parts of an object. The example we saw was a simple radio with a a pair of dials and a speaker, and when the iPad's camera was pointed at it, a circular interface along with a menu system popped up that cannily tracked the radio. From there, Huen mapped various songs onto different positions of the knob, allowing him to control his playlist by moving it -- a simple, manual interface for selecting music. He was even able to activate a second speaker by drawing a line to it, then "cutting" the line to shut it off. We're not sure when, or if, this kind of tech will ever make it into your house, but the demo we saw (see the pair of videos after the break) seemed impressively ready to go.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Qrv_8UvZdJU/

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92% Jurassic Park: An IMAX 3D Experience

All Critics (96) | Top Critics (24) | Fresh (97) | Rotten (8) | DVD (39)

The enthralling man-vs.-nature parable based on the late Michael Crichton's best-selling novel hasn't aged one bit.

The 3-D process adds not just dimension but depth - a technological extension of cinematographer Gregg Toland's deep-focus innovations in The Grapes of Wrath and Citizen Kane. The change in perspective creates greater intensity.

I'm a fan of this movie. It is thrilling, and the 3-D treatment is a nice enhancement.

This movie doesn't just stand the test of time, it transcends it.

"Jurassic Park" remains an absolute thrill from a Spielberg in top form: Funny, scary, fast-moving and full of just-right details.

"Jurassic Park" was impressive in 1993. Twenty years later, it's flawless.

A classic gets even better.

Steven Spielbeg's 1993 tale of an island plagued dinosaurs running amok holds up surprisingly well in the special effects category.

The film is a classic and the chance to see it on the big screen again (or for the first time) should not be missed

Sentiment is explained by science as the family impulse that motivates so many Steven Spielberg stories is revealed to be an evolutionary imperative in this near-perfect action-adventure.

[Looks] better not only than effects-driven movies of the same period, but better, frankly, than half of what gets released nowadays.

Kids who love dinosaurs will love it. And who doesn't?

confirms both Spielberg's mastery of cinematic thrills and the comparatively empty bombast of today's summer tentpole movies, even the better ones.

Jurassic Park shows us a director in transition, and the film captures his transformation in its own kind of cinematic amber.

[The] 3D [conversion] provides the definitive version of this classic film. Jurassic Park has been transformed with with artistry, nuance and sophistication, and it's an absolute must-see during this brief run.

The 3D effects had me nearly jumping out of my seat. Some say Hollywood is converting too many old films to 3D. But, "Jurassic Park" was the perfect choice. There's nothing more fun than sharing a seat with a snapping dinosaur.

Spielberg treats us as he does his characters, leading us into a strange land and expecting us to make it out with all our faculties intact; it's a tall order, given the heart-stopping, bloodcurdling, limbs-numbing excitement packed into the second hour.

It is as if time has passed the movie by. "Jurassic Park" remains solid entertainment, but the awe and wonder have faded.

The thrill of seeing live dinosaurs on screen is not as acute today as it was 20 years ago admittedly, but there is still some 3D awe left in the creations that roared 65 billion years ago...

The 3D isn't pushed on the audience, but it does reveal the amount of depth that Spielberg actually put into the film 20 years ago.

While it's not the most profound of Spielberg's works or the most entertaining from a popcorn perspective, it's one of the most technically flawless movies he's ever produced.

Jurassic Park 3D is like being reunited with an old friend; an old friend that wants to eat you and maul you to death, but still. A classic is reborn in glorious IMAX with a vibrantly stunning use of 3D.

If releasing the film in 3-D is the only way to get it back in theaters, then the gimmick is an acceptable addition. The 3-D is good. But when a movie is this near flawless, nothing is needed to make it better.

The 3D conversion ruins everything, like the comet that killed the dinosaurs, making Jurassic Park the rare amusement I'd prefer to revisit at home.

A beast of a movie is gifted a superfluous-but-superb rouging of the cheeks, offering fanatics something new to study while newcomers will be ruined for any future television airings.

Source: http://www.rottentomatoes.com/m/jurassic_park_an_imax_3d_experience_1993/

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Sunday, April 28, 2013

These Award-Winning Vines Are Everything a Six Second Film Should Be

Vines aren't exactly the newest from of high art. But while poorly edited Vine's of your friends' cats doing nothing are probably what you see most often, there are some pretty good ones, with a bit more meat to 'em. These Tribeca Vine Competition winners are a pretty good sample. They're so good you might even go "huh!" More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/-dE2Itrn1Xk/these-award+winning-vines-are-everything-a-six-second-film-should-be

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Saturday, April 27, 2013

How to ensure great music at your wedding - Artipot

Weddings are special and are carefully woven to include a series of events that make it a lifelong memory. In fact, whenever you would look at past experiences, you will notice that the recall factor associated to a wedding is it's festive ambience that the music creates. After all, it's the mesmerizing music that gets your guests moving to the dance floor. While choosing great wedding music is not a daunting task, you will still need to be cautious to be able to make the right decision. Everything from live bands to recorded music falls under the purview of wedding music. Your discretion will lie in choosing the right mix of different factors to ensure the perfect wedding music for your occasion.

Here is an elucidation of the basic tips that need to be kept in mind when it comes to choosing wedding music.

Know your guest list

Often, most of us end up becoming extremely busy planning other aspects of the wedding that we tend to ignore the music requirements. But this could lead to a disaster for your wedding. To avoid such mishaps, begin by knowing the demographics of the audience that you are expecting at the wedding. Accordingly prepare a music list that appeals to every age group. You can include a few personal favorites but don't go overboard with your choices forgetting it's a family affair.

Include variety but avoid repetition

As we have always emphasized, variety in the wedding music is a must. It keeps your guests entertained as well as engaged. Another disaster that has high chances of spoiling your event is repetition of songs and tunes in your wedding music. Don't think your guests won't notice just because they refuse to acknowledge it upfront.


Something for the senior citizens

A lot of the guests at a wedding are going to be old people who have come down all the way to bless the newly-weds. Ensure that your wedding music is not a pain to their ears. In fact, try to include some popular hits from their eras to make them feel special.

Guest requests

Yes! Ask your guests to send across requests for their favorite numbers and have them included in your wedding music playlist. This works well when you need extra time to fine tune the instruments or even cover up for a flaw.

Get your guests on the dance floor

A lot of the guests refuse to come to the dance floor due to their shyness. As a result of this half your dance time goes in convincing others. The best resort in such solutions is to get your guests started early when it comes to dancing. Once on the dance floor, its easy to let go of inhibitions and enjoy the festivities of the wedding.

Always have a list of don't plays

Yes! Most of us would be shocked to hear this. But just as you love to hear some songs, there are many songs that become a burden for the ear. Prepare a list of such don't plays and pass it on to the wedding music organizers. This will help them plan your wedding music better.

Source: http://www.artipot.com/articles/1563001/how-to-ensure-great-music-at-your-wedding.htm

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Friday, April 26, 2013

Reactor images first in 50 years

The first footage in 50 years has been taken of what lies inside the UK's first fast breeder nuclear reactor.

Digital cameras were inserted into the reactor housed within Dounreay's dome.

The cameras, designed and manufactured in nearby Wick, recorded images of the internal structures and the breeder fuel matrix.

Dounreay in Caithness was the centre of the UK fast breeder reactor research programme from 1954 until 1994. The site is now being demolished.

The images will help Dounreay Site Restoration Limited to prepare plans for the removal of radioactive fuel still inside the reactor, and the eventual dismantling of the reactor.

The dome is a steel sphere that was built between 1955 and 1958.

The fast reactor inside the dome was the first in the world to provide electricity to a national grid in 1962. Enough power was generated for a town the size of nearby Thurso, which has a population of between 7,000 and 9,000.

The reactor was shut down in 1977.

In 2011, plans to repaint the dome in Caithness at a cost of ?500,000 was cancelled.

David Stewart MSP had said the work would be a waste of money as the sphere was to be demolished.

The repaint had been done every 10 years to protect the dome's metal work.

DSRL said that following an assessment the steel was deemed thick enough to last as a protection until the reactor inside was dismantled.

Source: http://www.bbc.co.uk/news/uk-scotland-highlands-islands-22292053#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Sony prices its 2013 home and shelf audio lineups, clarifies ...

SONY UNVEILS 2013 HOME AUDIO PRODUCT LINE

The Company that has Kept Consumers In-Step to the Music for 50 Years Affirms its Commitment to the Best Sound Experience

Wide Array of Choices Meets the Home Audio System Needs of Any Consumer; Still the Only AV Receiver with Built-in Wi-Fi?, Bluetooth? and AirPlay?

LOS ANGELES, April 25, 2013 ? At a special listening and audition event today, Sony Electronics introduced its 2013 Home Audio product lineup, highlighting the STR-DN1040 Audio/Video Receiver and the HT-CT660 Soundbar. Available in June, both products boast of Sony's legendary commitment to quality sound, and are packed with connectivity and accessibility features. Both the STR-DN1040 receiver, priced at $599, and the HT-CT660 soundbar, priced at $399, will be available at Sony Stores and http://store.sony.com, as well as retailers nationwide.

"Our rich audio legacy leads consumers to expect continued innovation and performance from Sony audio products," said Neal Manowitz, director of Sony Electronics' Home Audio group. "The newest AV receiver in our line has the simplest, most user-friendly interface, which when combined with a world first and only AVR feature set of built-in Wi-Fi, AirPlay and Bluetooth connectivity, raises the bar with respect to usability, and does so with knockout sound performance. Likewise, the new soundbar extends the Sony line and brings theater-like, high-definition sound to any room in the house, with Bluetooth ease and convenience."

A Receiver Built for Sound ? and More

The STR-DN1040 AV Receiver delivers premium home theater performance with 7.2 Channel 1155 Watts (165 W x 7) of power and ten HD inputs (8 HDMI in), and features a newly redesigned chassis, an increased power transformer as well as Sony-designed capacitors and audio-grade transistors. "Just like a musical instrument, this AV receiver is specially tuned to bring out the very best sonic performance," said Aaron Levine, product marketing manager of Sony Electronics' Home Audio group. "There is a sonic performance reason for every part, every material, and every assembly technique put into this receiver."

Even at low sound levels, features such as Sound Optimizer maintain the nuances of the complete sound field, perfect for watching effects-laden motion pictures. Sony's innovative High Definition Digital Cinema Sound? (HD DCS) adds auditory depth for dramatic cinematic sound that faithfully reproduces the movie theater experience. Spectacular sound is further produced through support of Dolby? TrueHD, Pro Logic IIz and dts? HD enhanced audio codecs1. For outstanding picture performance, video signals can be converted up to 4K Ultra HD HDMI?. Complementing the sound performance is ample connectivity for HD and 4K Ultra HD devices, supporting both new and legacy connectivity.

Sony offers consumers the only AV receivers with built-in Wi-Fi, Bluetooth and AirPlay, and the STR-DN1040 receiver leads the way. Wi-Fi enables the STR-DN1040 receiver to easily access streaming media sources, and has integrated applications for Sony Entertainment Network's Music Unlimited, Pandora?, Slacker?, vTuner?, and more, as well as capabilities to seamlessly stream music from DLNA? enabled PCs. Moreover, with consumers more often accessing, storing, and playing music from mobile devices, the receiver also has built-in AirPlay and Bluetooth, allowing it to wirelessly receive the broadest amount of music from phones, tablets and computers. Users can also operate the receiver with the free Media Remote? app available for both iPhones? and Android? phones.

Also available in June is the STR-DN840 AV receiver, a 7.2 channel, 1050 Watt2 juggernaut with the same connectivity convenience of built-in Wi-Fi, Bluetooth and AirPlay. With six HDMI inputs, 4K pass-through, Sound Optimizer and more, the STR-DN840 is aggressively priced at just $449.

A Soundbar to Bring Boom to Any Room

Designed to bring the TV experience back to life, the HT-CT660 Soundbar is a 330 Watt system producing exceptional audio marked by rich, natural sounds and incredible clarity. The 2-way, 4-driver mica reinforced speaker system delivers exceptional sound clarity with detailed highs and lows, with big sound and minimal distortion, all complemented by a wireless subwoofer that brings feeling back to the low end, along with an added convenience of being able to be placed anywhere in the room. The three HDMI inputs allow easy connection to up to three devices, such as gaming consoles, Blu-ray Disc players and cable or satellite boxes, while delivering superior high-definition picture and sound quality. Movies are presented as directors intended, with Dolby? TrueHD and dts? HD Master Audio modes the reproduce high definition sound for uncompromised quality.

Adding to the soundbar's arsenal, Sony's S-Force? PRO Front Surround 3D technology synchronizes sounds to match the motion and depth of images on screen so viewers enjoy a fully immersive, simulated 3D surround experience without the bother and clutter of surround sound speakers.

Connecting the HT-CT660 soundbar with mobile devices such as phones and tablets to stream music is as simple as one touch of any Near-Field Communication (NFC) or Bluetooth enabled device. And with Bluetooth standby mode, you can start streaming and enjoying music without having to turn on any additional components.

Home Theaters to Bring Cinema to the Home

Sony also unveiled its complete Home Theater lineup, including the BDV-N8100W and BDV-N7100W "home theaters in a box." Both products feature 1000W, 5.1 channel 3D Blu-ray Disc Full HD 1080p playback, with built-in Wi-Fi to stream Netflix, HuluPlus, Pandora, the Sony Entertainment Network and more3, and wireless rear surround sound speakers. Additionally, NFC or Bluetooth enabled devices connect seamlessly with one touch. The BDV-N8100W system also features 3-way, 47-inch floor standing speakers for exceptional sound clarity and definition, with the upper portion of the speaker separable and ideal for wall-mounting installations.

Priced at $699 and $599 respectfully, the BDV-N8100W and BDV-7100W home theaters in a box are available now at Sony stores and online at http://store.sony.com, as well as electronics retailers nationwide.

SONY UNVEILS 2013 SHELF AUDIO SYSTEM PRODUCT LINE

Special Features Enhance Sound Quality from Any Source

Mini Systems Deliver Big Sound with Unprecedented Wireless Connectivity, Built in LED Lights Turn Any Room into a Nightclub

LOS ANGELES, April 25, 2013 ? At a special listening event today, Sony Electronics debuted new products from its 2013 Shelf System and Personal Audio lines. Available May 27, the products exemplify Sony's legendary commitment to music and sound, and are packed with easy to use connectivity and accessibility features.

"Music is the soundtrack of our lives, and for generations Sony has delivered innovative, fun devices for sharing music as a part of most every social occasion," said Andrew Sivori, vice president product marketing, Sony Electronics' Home Entertainment & Sound division. "Our newest audio products not only deliver explosive sound, but do so with easy connectivity and built-in lights ready to start the celebration at any time."

A Sound Machine You Not Only Hear, but See and Feel

The RDH-GTK37iP portable sound system is a 420 Watt mega-boombox party on-the-go, with connectivity features designed to get the party started with OneTouch. Simply touch Near-Field Communications (NFC) enabled mobile devices such as smart phones and tablets to the sound system to quickly and easily stream your favorite music. Devices without NFC capabilities can still connect easily through the system's built-in Bluetooth. Additionally, a front USB input connects MP3 players and flash drives, and an integrated docking system accommodates iPod and iPhone devices with ease.

Music is powered through a 2-way bass reflex speaker system with dual subwoofers, delivering 420 Watts total RMS power to ears in the room and beyond, and EQ and DJ effect controls let you customize the sound and take over as MC. But, the party doesn't stop just there, as the system speakers also incorporate multicolored LED/strobe lights to display illumination effects, turning any room into the hottest club. Priced at $349, the RDG-GTK37iP boombox will be available at Sony Stores and http://store.sony.com, as well as electronics retailers nationwide.

High Wattage Mini Systems Let the Neighbors Know the Block Party Has Started

Last year Sony brought more than a little shake, rattle and roll into its music lineup with the LBT-SH2000 high wattage mini system, a 2000 Watt powerhouse that gained king of the hill status in cities nationwide for its ability to deliver disruptive sound. Joining it in this year's lineup are the new LBT-GPX55 and LBT-GPX77 mini systems. Boasting 1600 and 1800 wall shaking Watts respectively, the LBT-GPX55 and LBT-DPXX77 mini systems both feature 3-way speaker systems and a single disc CD player, as well as dual front USB inputs for use with MP3 players and flash drives and also include Bluetooth audio streaming with simple NFC OneTouch pairing.

Both products feature EQ and DJ effects controls, letting consumers develop and customize their own signature sound, and the Sony Digital Sound Enhancement Engine (DSEE) restores life to compressed MP3 files. Like the RDH-GTK37iP system, the LBT-GPX77 model has selectable multicolored LED illumination to pulse with the music.

Starting at $499 for the LBT-GPX55, both mini-systems are available at Sony stores and http://store.sony.com, and electronics retailers nationwide.

Source: http://www.engadget.com/2013/04/26/sony-prices-and-dates-its-2013-home-and-shelf-audio-lineups/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Thursday, April 25, 2013

Gut bacteria byproduct predicts heart attack and stroke

Apr. 24, 2013 ? A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.

The research team was led by Stanley Hazen, M.D., Ph.D., Vice Chair of Translational Research, Chair of the Department of Cellular and Molecular Medicine for the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute at Cleveland Clinic, and W.H. Wilson Tang, M.D., Department of Cardiovascular Medicine in the Miller Family Heart and Vascular Institute and Lerner Research Institute.

The current study is an extension of Dr. Hazen's previous work, in which he found that a chemical byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin. The prior research showed that TMAO levels in the blood were associated with heart disease. Dr. Hazen and colleagues have now confirmed that gut flora are essential in forming TMAO in humans and demonstrated a relationship between TMAO levels and future cardiac events like heart attack, stroke, and death -- even in those with no prior evidence of cardiac disease risk.

To demonstrate the role of gut flora in forming TMAO, human subjects were asked to eat two hard-boiled eggs (a common dietary source of lecithin) and a capsule of labeled lecithin (as a tracer). After ingestion, TMAO levels in the blood increased. However, when these same subjects were given a brief course of broad-spectrum antibiotics to suppress their gut flora, their TMAO levels were suppressed, and no additional TMAO was formed, even after ingesting lecithin. These results demonstrated that the intestinal bacteria are essential for the formation of TMAO.

In the second phase of the study, the researchers measured TMAO levels in a large, independent, clinical cohort -- consisting of more than 4,000 adults undergoing cardiac evaluation at Cleveland Clinic -- over a three-year follow-up period. They found that higher TMAO blood levels were associated with higher future risks of death and nonfatal heart attack or stroke over the ensuing three-year period, independent of other risk factors and blood test results. These results complement those of another recent study of Dr. Hazen's linking gut flora metabolism of a structurally similar nutrient found in animal products, carnitine, to TMAO production and heart attack risk.

"Heart disease remains the No. 1 killer, and while we know how to reduce cholesterol, treat blood pressure, and reduce cardiac risks through diet and other interventions, a substantial residual risk still remains," Dr. Hazen said. "We need to find new pathways to attack heart disease, and these findings strongly suggest that further research into the involvement of gut microbiome in the development of cardiovascular disease could lead to new avenues of prevention and treatment of heart disease."

Dr. Hazen further suggested, "These studies show that measuring blood levels of TMAO could serve as a powerful tool for predicting future cardiovascular risk, even for those without known risk factors. More studies are needed to confirm that TMAO testing, like cholesterol, triglyceride or glucose levels, might help guide physicians in providing individualized nutritional recommendations for preventing cardiovascular disease. Our goal is not to suggest dietary restrictions of entire food groups. Eggs, meat and other animal products are an integral part of most individuals' diets. Our work shows, however, that when digesting these foods, gut flora can generate a chemical mediator, TMAO, that may contribute to cardiovascular disease."

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Story Source:

The above story is reprinted from materials provided by Cleveland Clinic, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. W.H. Wilson Tang, Zeneng Wang, Bruce S. Levison, Robert A. Koeth, Earl B. Britt, Xiaoming Fu, Yuping Wu, Stanley L. Hazen. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 2013; 368 (17): 1575 DOI: 10.1056/NEJMoa1109400

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/D14BpEQC7uQ/130424185211.htm

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For Corn, Fickle Weather Makes For Uncertain Yields

Missouri farmer Gary Riedel says wet weather will put him about a month behind last year's planting.

Abbie Fentress Swanson for NPR

Last year's drought wreaked havoc on farmers' fields in much of the Midwest, cutting crop yields and forcing livestock producers to cull their herds. This spring, the rain that farmers needed so badly in 2012 has finally returned. But maybe too much, and at the wrong time.

It's almost the end of April, which is prime time to plant corn. But farmers need a break in the rain so they can get this year's crops in the ground and try to lock in good yields at harvest.

"There are other things that can limit yield, and planting date isn't necessarily even the most important one," says University of Missouri agronomist Brent Myers. "But it is something we have to consider. And we want to try to get that corn planted in that timely window of, say, after the first week of April to the first week in May."

At his farm in Centralia, Mo., Gary Riedel, 69, in his green baseball cap and Western-style shirt, is just itching to plant corn on 1,000 acres of his 2,300-acre farm. He pulls open the lid from one of his planter's hoppers and shows me the salmon-colored corn seed that's all ready to go.

"Last year, I believe I started planting on the 28th of March, and this year, it may be the 28th of April, the way it's beginning to look," Riedel says. "It's just that the later we get, the more we are subject to problems from pollination due to hot weather."

Excessive heat and dryness can hurt corn pollination and stunt growth, leading to lower yields. So farmers try to plant early ? especially with corn still getting about $6.50 a bushel. (As The Salt reported last year, corn farmers made serious money, even though yields were down.) The U.S. Department of Agriculture says by this time last year, 26 percent of the country's corn crop was already planted. This year, farmers only have 4 percent of their corn in the ground.

We walk out to one of his misty fields, and Riedel points to the reason.

"See there, you can see a water puddle out in the field," he says. "We're going to have to wait till that dries up."

But even when the puddle dries, it still might take a while to get corn into the ground. Planting in cold, wet soil can cause all kinds of problems for corn seedlings, including that they can't take root or emerge above ground.

By this time last year, 16 percent of the country's corn crop was already planted. A wet, cold spring means that only 2 percent is in the ground right now.

Seth Perlman/AP

By this time last year, 16 percent of the country's corn crop was already planted. A wet, cold spring means that only 2 percent is in the ground right now.

Seth Perlman/AP

"We need some period of dry weather to help dry up the soil so producers can get out in the fields," says climatologist Pat Guinan, who has been forecasting the weather in Missouri for a quarter century. "Perhaps there may be some drier conditions, which will help. But right now, things are a little too wet across a good part of the state. And not only Missouri. Much of the Corn Belt is very wet. Especially from Iowa, over into Minnesota, parts of Wisconsin, Illinois and on into Indiana, we have some very wet conditions."

But even up until January, this moisture is what farmers had been hoping for. Last year's drought led to a 13 percent drop in corn production, which in turn led to tight corn stocks and increased competition for corn between ethanol plants and livestock producers. The shortfall is also hurting corn exports, which are now at a 40-year low.

"A good production year would mean there would be less competition and would improve margins," says Sterling Liddell, an agricultural economist with Rabo AgriFinance. "Especially in the cattle industry, which has suffered the most."

Last year's drought moved many farmers, including Gary Riedel, to increase the amount of crop insurance they carry. Peggy Smart, 77, also upped her coverage. Along with her family, she plants corn, soybeans and wheat on 6,000 acres of Missouri River bottomland in Tebbetts, Mo.

But nothing is planted yet. "We just don't have enough sunshine," she says.

Both Smart and Riedel are hoping to minimize the risks of bad weather by trying out drought- and flood-tolerant hybrid seeds this year. But first, they have to wait for the soil to dry out.

"It's just crazy that one year is one way and one is another," she says. "We don't have to go to Las Vegas to gamble, because farming is the biggest gamble there is."

Abbie Fentress Swanson reports from Missouri for Harvest Public Media, an agriculture-reporting project involving nine NPR member stations in the Midwest. For more stories about farm and food, check out Harvest Public Media.

Source: http://www.npr.org/blogs/thesalt/2013/04/24/177783540/for-corn-fickle-weather-makes-for-uncertain-yields?ft=1&f=1007

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Senate, House pursue sharply different paths to immigration reform

Senate's bill is sweeping, and it's moving fast. The House so far is taking up immigration reform piecemeal, and is proceeding at a, well, deliberative pace. Why are the approaches are so different?

By David Grant,?Staff writer / April 25, 2013

In this February photo, House Judiciary Committee Chairman Rep. Bob Goodlatte (R) of Virginia speaks on Capitol Hill in Washington. Rep. Goodlatte and Rep. Trey Gowdy (R) of South Carolina, who chairs the House subcommittee charged specifically with immigration policy, plan to push ahead on immigration reform by focusing on a few specific bills.

Susan Walsh/AP/File

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Two key House Republicans plan to push ahead on immigration reform by focusing on a few specific bills, keeping the issue before the chamber widely expected to have the hardest time with immigration reform legislation even as the Senate's sweeping, bipartisan bill speeds toward the finish line.???

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Whatever their differences in style and substance, though, immigration players in both Senate and House expressed confidence Thursday of approving some kind of reform before the year is out.?

?We do have a broken immigration system, and the House does intend to play a leading role in making sure this is solved,? said House Judiciary Committee Chairman Bob Goodlatte (R) of Virginia, whose panel oversees immigration law.

Mr. Goodlatte and Rep. Trey Gowdy (R) of South Carolina, who chairs the House subcommittee charged specifically with immigration policy, are starting with smaller pieces of the immigration puzzle rather than one overarching bill.?They say their committee's members will introduce two stand-alone measures ? one on foreign agricultural workers and one to make mandatory an employee verification system known as E-Verify ? as a first stab at immigration reform.

That drip-drip-drip approach contrasts markedly with action in the Senate, where two leaders on immigration reform on Thursday offered the hope that their sweeping measure could win significant bipartisan support.?Sens. Charles Schumer (D) of New York and John McCain (R) of Arizona argued that it is ?very possible? majorities of senators in both parties could support a comprehensive immigration reform solution, leading to a final tally of ?ayes? north of 70. ?

In that chamber, a bipartisan ?gang of eight? senators unveiled a comprehensive reform bill last week, and it has already had three hearings before the Senate Judiciary Committee. Sen. Pat Leahy (D) of Vermont, the panel's chairman, started the bill toward the Senate floor on Thursday by scheduling time to amend it in early May when Congress returns from a district work week.

Senate majority leader Harry Reid (D) of Nevada says the bill could hit the Senate floor for further debate and amendment in June.

At a breakfast with reporters sponsored by The Christian Science Monitor, Senators McCain and Schumer said they had taken care to anticipate the needs of their GOP colleagues, stripping from the bill a diversity visa program that conservatives dislike and ensuring that interests of Southern farmers are accommodated.?

?If we were to pass this bill with, say, over 50 Democratic votes ... but only eight or nine Republican votes, it would pass, we would get to 60, But it would bode poorly for [the reform effort in] the House,? Schumer said.

The bill's supporters want a bold, bipartisan Senate vote that will jolt the House, which has been pursuing a more deliberative tack on immigration reform.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/3gW23QIzQyQ/Senate-House-pursue-sharply-different-paths-to-immigration-reform

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Wednesday, April 24, 2013

Before Midnight Poster: Arrived!

Source: http://www.thehollywoodgossip.com/2013/04/before-midnight-poster-arrived/

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Thousands honor slain MIT officer

CAMBRIDGE, Mass. (AP) ? Slain Massachusetts Institute of Technology police officer Sean Collier was remembered Wednesday for his dedication to law enforcement and his love of people as thousands gathered at a campus memorial.

Vice President Joe Biden joined students, faculty and staff, and law enforcement officials from across the nation at Briggs Field for the service to honor an officer who was already well-respected by his colleagues and superiors, and popular with students after little more than a year on campus

Collier was fatally shot on April 18, three days after the Boston Marathon bombings that killed three people. Authorities say he was shot by brothers Tamerlan and Dzhokhar Tsarnaev. Dzhokhar Tsarnaev was charged Monday in his hospital room, where he is in fair condition with a gunshot wound to the throat suffered during his attempted getaway. His brother, 26-year-old Tamerlan, died Friday after a gunbattle with police.

"My heart goes out to you," Biden told Collier's family. "I hope you find some solace in this time of extreme grief."

Biden called the bothers suspected in the bombings and Collier's killing "two twisted, perverted, cowardly, knock-off jihadis"

He said he is constantly asked the question of why terrorists do what they do against the U.S.

"I've come to conclusion they do it to instill fear," Biden said. "To have us, in the name of our safety and security, jettison what we value most in the world, our open society, our system of justice that guarantees freedom. ... Our transparency; that's their target.

"It infuriates them that we refuse to bend, refuse to change, refuse to bend to fear."

Collier's casket was positioned in front of the thousands who gathered on a bright, sunny spring day. Music of bagpipes echoed through the field and a large American flag, suspended high about the crowd between two fire department ladder trucks, flapped slowly in the breeze.

Boston native James Taylor sang "The Water is Wide" and led a sing-along during "Shower the People."

Biden told the Colliers that no child should predecease their parents, and that better times are ahead.

"The moment will come ... when the memory of Sean is triggered and you know it's going to be OK," Biden said. "When the first instinct is to get a smile on your lips before a tear to your eye."

Andrew Collier said his 26-year-old brother would have loved everything about the day, including the bagpipes and the American flag.

"He was born to be a police officer and lived out his dream," Andrew Collier said.

MIT President L. Rafael Reif told those gathered that Collier made countless friends on campus.

"Sean Collier didn't have a job at MIT, he had a life at MIT," Reif said. "In just 15 months, he built a life with us. He touched people across our community."

Campus Police Chief John DiFava acknowledged the risk that accompanied the position of police officer, but questioned whether the risk of a job in law enforcement needed to come with such devastation.

"Sean left a lot behind," DiFava said. "He left us a lesson: Do it right!

"If you want to cherish his memory, remember to do it right," he said.

State police said between 4,000 and 5,000 attended the service. The line of mourners stretched for about a half mile at MIT ahead of the service. They had to make their way through tight security, including metal detectors and bomb-sniffing dogs ahead of the service.

"He is the one of the nicest people that I've ever met," said Kelly Daumit, 25, of Seattle, an engineering student at MIT who had gone on hikes with Collier as part of the MIT Outing Club. "Everything people are saying about him is completely genuine; it's not because of what happened."

MIT employee Larry Clark said he had only talked to Collier a couple of times but wanted to pay his respects.

"It's very tough. It's still a shock," he said.

Bagpipers played "Amazing Grace" as Collier's casket was carried from the service, and there was a fly-by with three helicopters over the campus.

A funeral was held for the officer on Tuesday.

Source: http://news.yahoo.com/slain-mit-officer-memorialized-campus-163649349.html

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First vaccine to help control some autism symptoms

Apr. 24, 2013 ? A first-ever vaccine created by University of Guelph researchers for gut bacteria common in autistic children may also help control some autism symptoms.

The groundbreaking study by Brittany Pequegnat and Guelph chemistry professor Mario Monteiro appears this month in the journal Vaccine.

They developed a carbohydrate-based vaccine against the gut bug Clostridium bolteae.

C. bolteae is known to play a role in gastrointestinal disorders, and it often shows up in higher numbers in the GI tracts of autistic children than in those of healthy kids.

More than 90 per cent of children with autism spectrum disorders suffer from chronic, severe gastrointestinal symptoms. Of those, about 75 per cent suffer from diarrhea, according to current literature.

"Little is known about the factors that predispose autistic children to C. bolteae," said Monteiro. Although most infections are handled by some antibiotics, he said, a vaccine would improve current treatment.

"This is the first vaccine designed to control constipation and diarrhea caused by C. bolteae and perhaps control autism-related symptoms associated with this microbe," he said.

Autism cases have increased almost sixfold over the past 20 years, and scientists don't know why. Although many experts point to environmental factors, others have focused on the human gut.

Some researchers believe toxins and/or metabolites produced by gut bacteria, including C. bolteae, may be associated with symptoms and severity of autism, especially regressive autism.

Pequegnat, a master's student, and Monteiro used bacteria grown by Mike Toh, a Guelph PhD student in the lab of microbiology professor Emma Allen-Vercoe.

The new anti- C. bolteae vaccine targets the specific complex polysaccharides, or carbohydrates, on the surface of the bug.

The vaccine effectively raised C. bolteae-specific antibodies in rabbits. Doctors could also use the vaccine-induced antibodies to quickly detect the bug in a clinical setting, said Monteiro.

The vaccine might take more than 10 years to work through preclinical and human trials, and it may take even longer before a drug is ready for market, Monteiro said.

"But this is a significant first step in the design of a multivalent vaccine against several autism-related gut bacteria," he said.

Monteiro has studied sugar-based vaccines for two other gastric pathogens: Campylobacter jejuni, which causes travellers' diarrhea; and Clostridium difficile, which causes antibiotic-associated diarrhea.

The research was supported by the Natural Sciences and Engineering Research Council.

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Story Source:

The above story is reprinted from materials provided by University of Guelph.

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Journal Reference:

  1. Brittany Pequegnat, Martin Sagermann, Moez Valliani, Michael Toh, Herbert Chow, Emma Allen-Vercoe, Mario A. Monteiro. A vaccine and diagnostic target for Clostridium bolteae, an autism-associated bacterium. Vaccine, 2013; DOI: 10.1016/j.vaccine.2013.04.018

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/0W9_AFl8Wv4/130424112309.htm

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Reese Witherspoon Arrest: Caught on Tape!

Source: http://www.thehollywoodgossip.com/2013/04/reese-witherspoon-arrest-caught-on-tape/

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Tuesday, April 23, 2013

As Boston buries its dead, more evidence gathered

BOSTON (AP) ? The Boston area held funerals for two more of its dead Tuesday ? including an 8-year-old boy ? as evidence mounted that the older Tsarnaev brother had embraced a radical, anti-American strain of Islam and was the driving force behind the Boston Marathon bombing.

Younger brother Dzhokhar Tsarnaev's condition was upgraded from serious to fair as investigators continued building their case against the 19-year-old college student. He could face the death penalty after being charged Monday with joining forces with his brother, now dead, in setting off the shrapnel-packed pressure-cooker bombs that killed three people.

In Washington, Senate Intelligence Committee member Richard Burr, R-N.C., said after his panel was briefed by federal law enforcement officials that there is "no question" that Tamerlan Tsarnaev, 26, was "the dominant force" behind the attacks, and that the brothers had apparently been radicalized by material on the Internet rather than by contact with militant groups overseas.

Martin Richard, a schoolboy from Boston's Dorchester neighborhood who was the youngest of those killed in the April 15 blasts at the marathon finish line, was laid to rest after a family-only funeral Mass.

"The outpouring of love and support over the last week has been tremendous," the family said in a statement. "This has been the most difficult week of our lives."

A funeral was also held for Massachusetts Institute of Technology police officer Sean Collier, 26, who authorities said was shot to death by the Tsarnaev brothers on April 18. A memorial service for Collier was scheduled for Wednesday at MIT, with Vice President Joe Biden expected to attend.

More than 260 people were injured by the bomb blasts. About 50 were still hospitalized.

Authorities believe neither brother had links to terror groups. However, two U.S. officials said Tuesday that Tamerlan Tsarnaev ? who died last week in a gunbattle ? frequently looked at extremist websites, including Inspire magazine, an English-language online publication produced by al-Qaida's Yemen affiliate. The magazine has endorsed lone-wolf terror attacks.

Both officials spoke on condition of anonymity because they were not authorized to discuss the investigation publicly.

On Capitol Hill, members of the Senate Intelligence Committee were briefed by the FBI and other law enforcement officials at a closed-door session Tuesday evening.

Afterward, Sen. Marco Rubio, R-Fla., described the two brothers as "a couple of individuals who become radicalized using Internet sources."

"So we need to be prepared for Boston-type attacks, not just 9/11-style attacks," Rubio said, referring to lone-wolf terrorists as opposed to well-organized teams from established terror networks.

Sen. Saxby Chambliss, R-Ga., said law enforcement officials have gotten "minimal" information from Dzhokhar Tsarnaev and are still looking into whether the brothers had training or coaching from a foreign group.

The brothers' parents live in Dagestan, a predominantly Muslim province in Russia's Caucasus, where Islamic militants have waged an insurgency against Russian security forces for years.

Family members reached in the U.S. and abroad by The Associated Press said Tamerlan was steered toward a strict strain of Islam under the influence of a Muslim convert known to the Tsarnaev family only as Misha.

After befriending Misha, Tamerlan gave up boxing, stopped studying music and began opposing the wars in Afghanistan and Iraq, according to family members, who said he turned to websites and literature claiming that the CIA was behind 9/11.

Somehow, he just took his brain," said Tamerlan's uncle, Ruslan Tsarni of Montgomery Village, Md., who recalled conversations with Tamerlan's worried father about Misha's influence.

"You could always hear his younger brother and sisters say, 'Tamerlan said this,' and 'Tamerlan said that.' Dzhokhar loved him. He would do whatever Tamerlan would say," recalled Elmirza Khozhugov, the ex-husband of Tamerlan's sister. He spoke by telephone from his home in Almaty, Kazakhstan.

The brothers, who came to the U.S. from Russia a decade ago, were raised in a home that followed Sunni Islam, the religion's largest sect, but were not regulars at the mosque and rarely discussed religion, Khozhugov said.

Then, in 2008 or 2009, Tamerlan met Misha, a heavyset bald man with a reddish beard. Khozhugov didn't know where they met but believed they attended a Boston-area mosque together.

Hoping to learn more about the motives, U.S. investigators traveled to southern Russia on Tuesday to speak to the parents of the two suspects, a U.S. Embassy official said.

A lawyer for the family, Zaurbek Sadakhanov, said the parents had just seen pictures of the mutilated body of their elder son and were not up to speaking with anyone.

In Massachusetts, the state House turned aside a bid by several lawmakers to reinstate the death penalty in certain cases, including the murder of police officers. In a 119-38 vote, the House sent the proposal to a study committee rather than advance it to an up-or-down vote.

In another development, April Walton, the manager of Phantom Fireworks of Seabrook, N.H., said Tamerlan Tsarnaev bought 48 mortar shells at the store in February.

Company Vice President William Weimer said FBI agents visited the store on Friday, interviewed staff and checked its computers. He said the amount of gunpowder that could be extracted would not have been enough for the Boston bombs.

___

Associated Press writers Bridget Murphy and Bob Salsberg in Boston, Lynn Berry in Moscow, and Adam Goldman, Eric Tucker, Matt Apuzzo, Kimberly Dozier and Eileen Sullivan in Washington contributed to this report.

Source: http://news.yahoo.com/boston-buries-dead-more-evidence-gathered-210532122.html

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Bringing Creativity to Public Education: Standing Behind Children and Teachers

As the U.S. Supreme Court hears arguments on gay marriage, Yahoo asked readers and contributors to share what one cultural issue absorbs their interest. Here's one perspective.

COMMENTARY | Standardized testing is taking our children and our teachers hostage. A teacher in Ohio's public schools myself, I was recently told by an administrator: "Sure, creative projects are nice, but the reality is we need to prepare kids for the test."

Translation: You need to do more worksheets, more practice bubbletrons with your students. Creativity doesn't count here.

However, in real reality, creativity solves problems much bigger than "choose the best answer."

Intelligent, out-of-the-box thinking students regularly tell me how stupid they feel because they can't "figure out" what the test wants from them.

It breaks my heart when my daughter -- a fun-loving, passionate animal lover -- cries after school because her 2nd grade teacher spent 2 hours on Math test prep at school and now she has another 45 minutes of homework.

The biggest social concern of our age is to take the school-as-prison mentality and turn it into school as-invention-studio. We start by training teachers in alternative practices such as Waldorf, Montessori, and Reggio Emilia. Then, like Ohio's Cincinnati Public Schools, we bring these alternative practices into the public sphere.

As parents, we have to stand beside our teachers and say to our legislators and administration: no more testing, no more industrialization of education. Bring creativity and love of learning out of the privilege of private schools and into the public school realm where everyone has access.

Finland has it right. Creativity for teachers and students counts -- it's about educating for life, not for a test.

Source: http://news.yahoo.com/bringing-creativity-public-education-standing-behind-children-teachers-181400444.html

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Monday, April 22, 2013

E.L. Konigsburg: best remembered for 'From the Mixed-Up Files of Mrs. Basil E. Frankweiler'

E.L Konigsburg won the Newbery Medal twice and is best known for her children's book 'From the Mixed-Up Files of Mrs. Basil E. Frankweiler.'

By Molly Driscoll,?Staff Writer / April 22, 2013

E.L. Konigsburg is the author of 'From the Mixed-Up Files of Mrs. Basil E. Frankweiler' and 'The View from Saturday,' as well as other award-winning children's books.

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Children?s author E.L. Konigsburg, a two-time Newbury Medalist for her books ?From The Mixed-Up Files of Mrs. Basil E. Frankweiler? and ?The View from Saturday,? died on April 19 at the age of 83, according to her family.

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Konigsburg was perhaps best known for the 1967 book ?From The Mixed-Up Files of Mrs. Basil E. Frankweiler,? which followed a brother and sister, Claudia and Jamie, who ran away from home and hid inside New York?s Metropolitan Museum of Art.?

Konigsburg, whose full name was Elaine Lobl, grew up in Pennsylvania and attended Carnegie Mellon University, majoring in chemistry. Konigsburg began writing and illustrating books after her youngest child had entered school and published her first book, ?Jennifer, Hecate, Macbeth, William McKinley, and Me, Elizabeth,? in 1967. ?From The Mixed-Up Files of Mrs. Basil E. Frankweiler? came out later the same year.

The author?s other works included ?Up from Jericho Tell? and ?The View from Saturday,? which was released in 1996 and followed a group of middle-schoolers who enter an academic competition. ?From The Mixed-Up Files of Mrs. Basil E. Frankweiler? won the Newbery Medal in 1968 and ?Jennifer, Hecate, Macbeth, William McKinley, and Me, Elizabeth,? secured a Newbery Honor that same year, making her the only author to win both a Medal and an Honor in the same year. Konigsburg later won the Medal again in 1997 for ?The View from Saturday,? making her one of only five authors to have been given the prize twice.

?From The Mixed-Up Files of Mrs. Basil E. Frankweiler? was adapted once as a 1973 film called ?The Hideaways,? in which actress Ingrid Bergman starred as the title character, and again in 1995 as a TV movie in which Lauren Bacall took on the part.

Konigsburg wrote that she was inspired to create the story of ?From The Mixed-Up Files of Mrs. Basil E. Frankweiler? after she and her family went on a picnic and her children complained of the discomfort involved.

?What, I wondered, would my children do if they ever decided to leave home?? the author said. ?Where, I wondered, would they go? At the very least, they would want all the comforts of home, and they would probably want a few dashes of elegance as well. They would certainly never consider any place less elegant than the Metropolitan Museum of Art."

In Konigsburg?s novel, protagonist Claudia ?knew that she could never pull off the old-fashioned kind of running away,? the author writes. ?She didn't like discomfort; even picnics were untidy and inconvenient: all those insects and the sun melting the icing on the cupcakes.?

The author?s last book, ?The Mysterious Edge of the Heroic World,? was released in 2007.

?I think most of us are outsiders,? Konigsburg told the Dallas Morning News of her characters. ?And I think that?s good because it makes you question things. I?think it makes you see things outside yourself.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/G7W0WWQ6X6g/E.L.-Konigsburg-best-remembered-for-From-the-Mixed-Up-Files-of-Mrs.-Basil-E.-Frankweiler

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Insight: How eurozone backwater Slovenia became its latest liability

By Michael Winfrey and Marja Novak

LJUBLJANA (Reuters) - Igor Luksic, leader of the Social Democrats in Slovenia's ruling coalition, disagrees with the European leaders who say his country should privatize its three biggest lenders to avoid the misery of another bailout in the euro zone.

The political science lecturer who has lined his office with portraits of Martin Luther King, John Kennedy, Mahatma Gandhi and Che Guevara said his party would fight the move.

"We have always been against selling banks," said Luksic, whose party is the second largest in Prime Minister Alenka Bratusek's government.

The banks in the Alpine former Yugoslav republic of 2 million people are a key reason why it showed up on the agenda of Friday's Dublin meeting of the bloc's 27 finance ministers on preventing a new eurozone debt crisis.

"Slovenia is facing serious challenges," EU Economic and Monetary Affairs Commissioner Olli Rehn told Reuters on Thursday, calling for decisive action to restructure and recapitalize the banking sector among other urgent measures.

Financial market pressure on Slovenia has lain bare how this tiny euro zone state achieved Europe's smoothest transformation from a Communist economy to a market-based model: it only went half way.

While former Soviet satellite states like Poland and the Czech republic privatized big firms, slashed budgets, and pushed through other reforms, Slovenia held on to public assets, avoided cost cuts and repeatedly bailed out state banks after escaping the violent breakup non-aligned Yugoslavia in 1992.

That has now become a liability for Bratusek who, after last month's chaotic rescue of Cyprus, is scrambling to stop a spike in Slovenia's borrowing costs and convince investors it can change its ways and avoid insolvency.

Bratusek, who took power only four weeks ago, has pledged to break taboo by imposing unpopular austerity measures and selling at least one of the publicly owned companies that make up as much as half of the economy, and possibly a bank.

Luksic stopped short of threatening to quit the coalition if it privatized the banks, but the cabinet has not rejected its predecessor's plan for Ljubljana to keep blocking stakes in the main two ones, which experts say will prevent their sale.

The coalition of parties whose members range from neo-liberal centrists to leftists, is not united on other reforms either, and may face staunch opposition from voters.

"Slovenia did not embrace reforms because it did not have to," said Borut Hocevar, an analyst at the daily Finance.

"Everything seemed fine on the surface until a few years ago but now it is clear that banks were used as a tool of political and economic elites and that Slovenia would be much better off if it had sold them a while ago."

WAVERING FAME

From its immaculate highways to the trendy shops and bars in its capital Ljubljana, Slovenia resembles developed EU states like Austria and Germany far more than its ex-Communist peers.

With living standards measured at 84 percent of the EU average, it has leapfrogged euro zone laggards Portugal and Greece and enjoys more than twice the standard of Serbia, from which it split when it left the former Yugoslavia in 1991.

But, following a nasty downturn and spike in the budget deficit, its once enviable debt levels have doubled to 54 percent of gross domestic product.

Last week the Paris-based Organisation for Economic Cooperation and Development (OECD) warned the debt level, fuelled by the cost of saving Slovenia's banks plus healthcare, pension, and other costs, could reach 100 percent by 2015 if Ljubljana does not embrace reform.

Luksic acknowledged his party might not prevail in its attempt to stop the banks being privatized but said at the very least the biggest bank Nova Ljubljanska Banka or NLB, should stay in state hands, since it could become a big regional bank.

"This is the tool that the state, as a national state, should use for promoting its perception of how the state should develop," he said.

Foreign institutions have for years criticized successive governments' for stifling competition and investment and say it has avoided painful reforms that its regional peers embraced.

Spending by the state is about 50 percent of gross domestic product, one of the highest levels of the OECD club of wealthy countries. Governments have also repeatedly rejected foreign bids to buy state-owned firms, most recently killing the sale of leading grocery chain Mercator to a Croatian rival in 2011.

Protecting national interests, diplomats, business leaders, and others say, is also tangled with corruption and cronyism in Slovenia's small ruling elite and will be a hard habit to break.

"Whenever they want to keep something because they are connected in some way with the business or a certain group of people because they have interests in those businesses, they always throw up this concept of national interest, when really it's personal interest," a Western diplomat told Reuters.

"Everyone has convinced themselves that it's truly in the best interest of the country to work in this way, because it worked for 20 years and they were the model for the rest of the former communist countries," said the diplomat who declined to be identified.

The combination of state ownership, a tight-knit political network, and bad management helped trigger the lending spree from state banks that, following a collapse in real estate prices, has gone sour.

Bratusek plans to shift some of the 7 billion euros in bad loans choking mostly the banks NLB, Abanka Vipa, and Nova KBM, in which the state is either the majority or a strategic stakeholder, to a "bad bank" in June.

The government must then pump some 1 billion euros of new capital into them this year - the OECD says maybe much more - with the aim of selling them, even though bankers, analysts and diplomats say there are no prospective buyers for now.

It is not the first time the government has had to bail out its banks. It has injected capital into NBL - which needs an estimated 375 million euros this time around - on five separate occasions.

"It has been proven that foreign owners are better," said Tomaz Boltin, the head of Slovenia's banking sector union. Selling them "is the only way to cut the cycle in which banks are used to finance the political and economic elite," he said.

OBSTACLES

But it may be hard to convince voters. It was a wave of protests against austerity measures - and graft - that helped topple Bratusek's predecessor.

"I think the government should not sell banks and other state companies which are the property of us all," said Omar Beckanovic, a retired builder at Ljubljana's main open market.

Although Bratusek can find support for the measures from the center-right opposition, parties within her own coalition could oppose them, which could destabilize her fragile cabinet.

Another risk is the role of plebiscites in Slovenia, where anyone can demand a vote to knock down a newly passed law by gathering 40,000 signatures. Unions have used them to attack laws on belt-tightening and state asset sales.

There are already signs Bratusek is softening on austerity. In talks with unions, her government has trimmed a plan to cut public sector wages to 158 million euros from some 255 million envisaged by the previous, right of center, government.

Last week, it postponed a debate in parliament on the fiscal "golden rule" which calls for a balanced structural budget by 2015, and Luksic's party has said balancing the budget should take longer to shield poorer Slovenes.

Andrew Page, Britain's ambassador to Slovenia said reforms could require a significant shift. "The challenge here is not just to bring one or two political parties with the Prime Minister but actually to begin to change public perceptions."

(Editing by Philippa Fletcher)

Source: http://news.yahoo.com/insight-eurozone-backwater-slovenia-became-latest-liability-143516673--business.html

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